Know your quantitative antibody levels to determine how you responded to the vaccine.


Frequently Asked Questions (FAQs)

Are you immune after you are vaccinated?

Not necessarily, there is at least a 5% chance you are not immune. Current reports show that some vaccines protect up to 95% of people vaccinated while others protect up to 76%. No vaccine guarantees 100% immunity.

How do I know if I'm immune?

Currently there is not yet a procedure proven to determine if you are immune to the virus. It is known that antibodies to the receptor binding domain (RBD) and S1 subunit of the viral spike protein are highly associated with blocking the virus from infecting cells in a test tube. However, currently no one has yet proven they provide immunity.

Here is what we do know!

One hundred twenty-two sailors went on a fishing expedition. One hundred twenty were tested for the virus and all were negative when they left port. Upon return 104 had COVID-19. Three of the sailors had RBD antibodies before leaving port and did not get COVID-19. None of the other 117 tested had RBD antibodies. The chances of that randomly occurring are 1 in 400, generally if random chance is less than 1 in 100, the statistical relevance is strong. This is a small study, but highly significant.

The monoclonal therapies that have FDA emergency use authorization (EUA) use antibodies that are directed at the RBD. These therapies have been shown to lessen the severity of COVID-19 as well as shorten its course.

People given the Moderna or Pfizer vaccines have been shown to have high levels of antibodies to RBD and the S1 subunit.

COVID-19 patients who receive plasma from others who have recovered from the disease and have high levels of anti-spike protein antibodies, had less severe disease.

Quantitative levels of IgG to RBD are closely associated with the ability to neutralize virus in the test tube. Patients with higher levels of anti-RBD required less of their serum to neutralize the COVID-19 virus.

These and other studies demonstrate that antibodies to the RBD and S1 protein are highly associated with virus neutralization and may be important in fighting the disease.

The U.S. Food and Drug Administration (FDA) has taken the position that testing positive for COVID-19 neutralizing antibodies does not necessarily mean that a patient is protected from COVID-19. So, patients and providers still need to follow public health precautions.

What makes the Allermetrix COVID-19 Antibody test different from others?

Other current COVID-19 serology tests are qualitative which only tell you if you have antibodies or not. Allermetrix serology is quantitative and indicates how many antibodies you have. The higher level of antibodies, the more viruses that can be neutralized.

What do my results mean?

Your results should be reviewed with your healthcare provider to understand how they relate to you.

What does "CAP Accredited" mean?

As the world's largest organization of board-certified pathologists and leading provider of laboratory accreditation and proficiency testing programs, the College of American Pathologists (CAP) serves patients, pathologists, and the public by fostering and advocating excellence in the practice of pathology and laboratory medicine worldwide.